PR001451 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20251214.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M85H8N

Description:Several adult omics studies have been conducted to understand the pathophysiology of nonalcoholic fatty liver disease (NAFLD). However, the histological features of children are different from those of adults, and the onset and progression of pediatric NAFLD are not fully understood. In this study, we aimed to evaluate the metabolome profile and metabolic pathway changes associated with pediatric NAFLD to elucidate its pathophysiology. We analyzed the metabolic profiles of healthy control, lean NAFLD, overweight control and overweight NAFLD groups of children and adolescent participants (n = 165) by assessing plasma samples, and identified 18 NAFLD-specific metabolic features and metabolic changes in lipid, glutathione-related amino acid, and branched-chain amino acid metabolism by comparing control and NAFLD group in pediatric population with overweight. Metabolome changes in the plasma of pediatric patients with NAFLD are associated with the pathophysiology of the disease and can be utilized as a less-invasive approach to diagnose the disease.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU002355 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001451 project
	ST002269 p400 Data.zip File (Entity type)	A 4.93 GB file from Metabolomics produced from OBI:0000470 as part of the PR001451 project
	SA217701 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001451 project
	SA217706 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001451 project
	SA217620 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001451 project
	SA217697 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001451 project
	SA217564 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001451 project
	SA217667 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001451 project
	SA217726 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001451 project