PR002440 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M87N91

Description:Tweety homolog 1 (TTYH1) is an understudied protein designated by the Illuminating the Druggable Genome Program of the NIH. While previous studies implicated its functions in neural stem cell signaling and glioma invasion, little is known about the molecular function of TTYH1. Recent cryo-electron microscopy examination of TTYH1 revealed its potential role in transporting membrane lipids, leading to our hypothesis that TTYH1 regulates intracellular lipid homeostasis. Orthologs of TTYH1 have been identified across animal species including worm and fruit fly. Similar to human TTYH1, fly TTYH1 ortholog, named tweety (tty), is also predominantly expressed in the brain. To examine whether TTYH1 exerts its cellular functions via regulating lipid homeostasis, we profiled the lipidome in fruit fly (Drosophila melanogaster) head tissues isolated from wild-type (w-1118 strain) and tty mutant (tty-MI12269 strain) flies.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU004034 Subject (Entity type)	A subject from Metabolomics produced as part of the PR002440 project
	SU004035 Subject (Entity type)	A subject from Metabolomics produced as part of the PR002440 project
	SA429588 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002440 project
	SA429590 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002440 project
	SA429579 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002440 project
	SA429578 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002440 project
	SA429587 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002440 project
	SA429582 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002440 project
	SA429580 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002440 project

PPR00001

Project (Entity type)

Metabolomics

SU004034

Subject (Entity type)

A subject from Metabolomics produced as part of the PR002440 project

SU004035

Subject (Entity type)

A subject from Metabolomics produced as part of the PR002440 project

SA429588

Biosample (Entity type)