PR001147 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8FH7R

Description:The lack of knowledge about the onset and progression of Parkinson’s disease (PD) hampers its early diagnosis and treatment. We used a multiplatform untargeted metabolomics-based approach to uncover the biochemical remodeling induced by PD in a really early and pre-symptomatic stage and unveiling early potential diagnostic biomarkers. Baseline pre-clinical plasma samples (Pre-PD n=39; control group n=39) were obtained from the European Prospective Study on Nutrition and Cancer (EPIC) cohort, which healthy volunteers were followed for around 15 years to ascertain incident PD. Our finding revealed alterations in fatty acids metabolism, mitochondrial dysfunction, oxidative stress, and gut-brain axis dysregulation. This study is of inestimable value since this is the first study conducted with samples collected many years before the disease development.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU001891 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001147 project
	SA168905 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001147 project
	SA168840 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001147 project
	SA168865 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001147 project
	SA168885 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001147 project
	SA168856 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001147 project
	SA168835 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001147 project
	SA168896 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001147 project
	SA168859 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001147 project

PPR00001

Project (Entity type)

Metabolomics

SU001891

Subject (Entity type)

A subject from Metabolomics produced as part of the PR001147 project

SA168905

Biosample (Entity type)