PR002485 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20251214.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8F25H

Description:The goal of this project was to measure metabolite shifts in Mycobacterium tuberculosis (Mtb) in response to desiccation and rehydration. We characterized the metabolome of Mtb in log phase and compared it to cells that were either dried for 24 hours or held in a solution of 200 mM sodium chloride. Following this incubation cells were rehydrated into 200 mM sodium chloride. We performed targeted metabolomics on each of these conditions using LC-MS. Significant increases in oxidized nucleotides and intermediates of de novo nucleotide biosynthesis were discovered in the desiccated samples. These metaboite accumulations reversed with rehydration.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU004106 Subject (Entity type)	A subject from Metabolomics produced as part of the PR002485 project
	ST003969 Desiccation metabolomics.zip File (Entity type)	A 3.61 GB file from Metabolomics produced from OBI:0003097 as part of the PR002485 project
	SA453134 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002485 project
	SA453106 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002485 project
	SA453124 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002485 project
	SA453116 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002485 project
	SA453123 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002485 project
	SA453133 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002485 project
	SA453156 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002485 project

PPR00001

Project (Entity type)

Metabolomics

SU004106

Subject (Entity type)

A subject from Metabolomics produced as part of the PR002485 project

ST003969 Desiccation metabolomics.zip

File (Entity type)

A 3.61 GB file from Metabolomics produced from OBI:0003097 as part of the PR002485 project

SA453134

Biosample (Entity type)