PR001918 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20251214.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8ST6K

Description:The embryonic cerebrospinal fluid (eCSF) is critical for the developing central nervous system (CNS), from neurogenesis to lifelong cognitive functions. Changes in eCSF composition due to inflammation can impact brain function. We recently identified an abnormal cytokine signature in eCSF following maternal immune activation (MIA), a mouse model of autism spectrum disorder (ASD). We hypothesized that MIA leads to other alterations in eCSF composition and employed untargeted metabolomics to profile changes in the eCSF metabolome in mice after inducing MIA with polyI:C. We report these data here as a resource, including a comprehensive MS1 and MS2 reference dataset, and present additional datasets comparing two mouse strains (CD-1 and C57Bl/6) and two developmental time points (E12.5 and E14.5). Targeted metabolomics further validated changes in eCSF upon MIA. We show a significant elevation of glucocorticoids and kynurenine pathway related metabolites. Both pathways are relevant for suppressing inflammation or could be informative as disease biomarkers. Our resource should inform future mechanistic studies regarding the etiology of MIA neuropathology and roles and contributions of eCSF metabolites to brain development.

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Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU003194 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001918 project
	SU003197 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001918 project
	SU003203 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001918 project
	SU003198 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001918 project
	SU003195 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001918 project
	SU003196 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001918 project
	SU003201 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001918 project
	SU003200 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001918 project
	SU003199 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001918 project