PR001976 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M89J06

Description:Rheumatoid arthritis (RA) is a bundle of systemic inflammatory diseases mainly affecting the joints, complicating the identification of biomarkers for early diagnosis, predicting disease progress and therapeutic outcomes. This study scrutinizes a longitudinal cohort of RA, inclusive of follow-ups, alongside OA, UA and ACPA/RF-RA and healthy controls, aiming to discover plasma metabolic markers that can precede RA onset, assess disease activity, and forecast treatment efficacy. Our investigation revealed substantial metabolic alterations at both the pathway and individual metabolite levels across RA, at-risk or RA and healthy control. The drug response predictive models constructed on critical differential metaboites showed optimal performance. Additionally, our longitudinal data sheds light on the molecular impacts on metabolism of csDMARDs in RA.

Results found

Linked to

	Label	Description
	SU003296 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001976 project
	PPR00001 Project (Entity type)	Metabolomics
	SA343622 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001976 project
	SA345088 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001976 project
	SA344639 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001976 project
	SA345242 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001976 project
	SA345159 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001976 project
	SA343602 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001976 project
	SA345297 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001976 project
	SA344807 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001976 project

SU003296

Subject (Entity type)

A subject from Metabolomics produced as part of the PR001976 project

PPR00001

Project (Entity type)

Metabolomics

SA343622

Biosample (Entity type)