PR000409 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20251214.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8602H

Description:Diabetic nephropathy (DN) is the leading cause of end stage renal disease, and is associated with high morbidity and mortality rates. The pathophysiology of DN includes both glomerular and tubulointerstitial damage. Meprins are metalloproteinases which are most abundantly expressed in the brush border membranes of proximal kidney tubules. Meprins are also expressed in leukocytes (monocytes and macrophages) and podocytes. Meprins have been implicated in the pathology of acute and chronic kidney injury. Single nucleotide polymorphisms (SNPs) in the meprin ß gene were associated in human DN in the Pima Indians, suggesting a role for meprins in the pathophysiology of DN. The current study was done to determine the mechanisms by which meprins modulate the progression of DN in mice.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU000580 Subject (Entity type)	A subject from Metabolomics produced as part of the PR000409 project
	ST000558.zip File (Entity type)	A 63.2 GB file from Metabolomics produced from OBI:0003097 as part of the PR000409 project
	SA028818 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000409 project
	SA028791 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000409 project
	SA028807 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000409 project
	SA028827 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000409 project
	SA028784 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000409 project
	SA028783 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000409 project
	SA028804 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000409 project

PPR00001

Project (Entity type)

Metabolomics

SU000580

Subject (Entity type)

A subject from Metabolomics produced as part of the PR000409 project

ST000558.zip

File (Entity type)

A 63.2 GB file from Metabolomics produced from OBI:0003097 as part of the PR000409 project

SA028818

Biosample (Entity type)