PR001872 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20251214.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8R41G

Description:Neuroendocrine alterations in the mid-life hypothalamus coupled with reproductive decline herald the initiation of menopausal transition. The certain feature and contribution of gut microflora and metabolites to neuroendocrine changes in the menopausal transition remain largely unknown. Fecal samples of rats experiencing different reproductive stages were collected and processed for 16S rRNA and liquid chromatography-mass spectrometry sequencing. The differences of gut microbiota and metabolites between young and middle-aged rats during proestrus and diestrus were analyzed and their relationships to neuroendocrine aging were then examined. This study documents specific gut microbial composition changes and concomitant shifting trends of metabolites during menopausal transition, which may initiate the gut-brain dysfunction in neuroendocrine aging.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU003117 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001872 project
	ST003003 POS rawdata.zip File (Entity type)	A 3.10 GB file from Metabolomics produced from OBI:0003097 as part of the PR001872 project
	ST003003 NEG rawdata.zip File (Entity type)	A 2.36 GB file from Metabolomics produced from OBI:0003097 as part of the PR001872 project
	ST003003 AN004934 Results.txt File (Entity type)	A 42.4 KB file from Metabolomics produced from OBI:0003097 as part of the PR001872 project
	ST003003 AN004933 Results.txt File (Entity type)	A 73.8 KB file from Metabolomics produced from OBI:0003097 as part of the PR001872 project
	SA326823 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001872 project
	SA326821 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001872 project
	SA326835 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001872 project
	SA326824 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001872 project

PPR00001

Project (Entity type)

Metabolomics

SU003117

Subject (Entity type)

A subject from Metabolomics produced as part of the PR001872 project

ST003003 POS rawdata.zip

File (Entity type)

A 3.10 GB file from Metabolomics produced from OBI:0003097 as part of the PR001872 project

ST003003 NEG rawdata.zip

File (Entity type)

A 2.36 GB file from Metabolomics produced from OBI:0003097 as part of the PR001872 project

ST003003 AN004934 Results.txt

File (Entity type)

A 42.4 KB file from Metabolomics produced from OBI:0003097 as part of the PR001872 project

ST003003 AN004933 Results.txt

File (Entity type)

A 73.8 KB file from Metabolomics produced from OBI:0003097 as part of the PR001872 project

SA326823

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001872 project

SA326821

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001872 project

SA326835

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001872 project

SA326824

Biosample (Entity type)

A biosample from Metabolomics produced as part of the PR001872 project

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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