PR001872 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8R41G

Description:Neuroendocrine alterations in the mid-life hypothalamus coupled with reproductive decline herald the initiation of menopausal transition. The certain feature and contribution of gut microflora and metabolites to neuroendocrine changes in the menopausal transition remain largely unknown. Fecal samples of rats experiencing different reproductive stages were collected and processed for 16S rRNA and liquid chromatography-mass spectrometry sequencing. The differences of gut microbiota and metabolites between young and middle-aged rats during proestrus and diestrus were analyzed and their relationships to neuroendocrine aging were then examined. This study documents specific gut microbial composition changes and concomitant shifting trends of metabolites during menopausal transition, which may initiate the gut-brain dysfunction in neuroendocrine aging.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU003117 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001872 project
	SA326838 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001872 project
	SA326823 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001872 project
	SA326821 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001872 project
	SA326839 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001872 project
	SA326835 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001872 project
	SA326824 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001872 project
	SA326837 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001872 project
	SA326833 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001872 project

PPR00001

Project (Entity type)

Metabolomics

SU003117

Subject (Entity type)

A subject from Metabolomics produced as part of the PR001872 project

SA326838

Biosample (Entity type)