PR000603 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20251214.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8QQ3S

Description:A goal of biology is to predict the phenotypes of individuals, such as side effects to drugs, from their genotypes. Genetic variants that cause disease can change an individual’s total metabolite profile, or metabolome. Understanding the function of these genetic variants may help predict novel phenotypes. We used an unbiased method in yeast to show that genetic differences in two genes change the levels of several urea cycle metabolites. Leveraging knowledge of the urea cycle, we then predicted and validated the sensitivity of yeast strains to a particular drug. The interpretability of our results demonstrates the promise of using genetic variants underlying differences in the metabolome to predict novel phenotypes from genotype.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU000907 Subject (Entity type)	A subject from Metabolomics produced as part of the PR000603 project
	SU000905 Subject (Entity type)	A subject from Metabolomics produced as part of the PR000603 project
	SU000906 Subject (Entity type)	A subject from Metabolomics produced as part of the PR000603 project
	ST000868.zip File (Entity type)	A 532 MB file from Metabolomics produced from OBI:0000470 as part of the PR000603 project
	ST000871.zip File (Entity type)	A 532 MB file from Metabolomics produced from OBI:0000470 as part of the PR000603 project
	ST000870.zip File (Entity type)	A 532 MB file from Metabolomics produced from OBI:0000470 as part of the PR000603 project
	ST000870 AN001417 Results.txt File (Entity type)	A 1.86 MB file from Metabolomics produced from OBI:0000470 as part of the PR000603 project
	ST000868 AN001416 Results.txt File (Entity type)	A 259 KB file from Metabolomics produced from OBI:0000470 as part of the PR000603 project
	ST000871 AN001415 Results.txt File (Entity type)	A 348 KB file from Metabolomics produced from OBI:0000470 as part of the PR000603 project

PPR00001

Project (Entity type)

Metabolomics

SU000907

Subject (Entity type)

A subject from Metabolomics produced as part of the PR000603 project

SU000905

Subject (Entity type)

A subject from Metabolomics produced as part of the PR000603 project

SU000906

Subject (Entity type)

A subject from Metabolomics produced as part of the PR000603 project

ST000868.zip

File (Entity type)

A 532 MB file from Metabolomics produced from OBI:0000470 as part of the PR000603 project

ST000871.zip

File (Entity type)

A 532 MB file from Metabolomics produced from OBI:0000470 as part of the PR000603 project

ST000870.zip

File (Entity type)

A 532 MB file from Metabolomics produced from OBI:0000470 as part of the PR000603 project

ST000870 AN001417 Results.txt

File (Entity type)

A 1.86 MB file from Metabolomics produced from OBI:0000470 as part of the PR000603 project

ST000868 AN001416 Results.txt

File (Entity type)

A 259 KB file from Metabolomics produced from OBI:0000470 as part of the PR000603 project

ST000871 AN001415 Results.txt

File (Entity type)

A 348 KB file from Metabolomics produced from OBI:0000470 as part of the PR000603 project

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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