PR001374 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M84127

Description:Dietary fructose, especially in the context of a high-fat western diet, has been linked to type 2 diabetes. Although the effect of fructose on liver metabolism has been extensively studied, a significant portion of the fructose is first metabolized in the small intestine. Here we report that dietary fat enhances intestinal fructose metabolism, which releases glycerate into the blood. High systemic glycerate levels reduce pancreatic islet sizes and ß-cell content, thus inducing glucose intolerance. Our findings provide an additional link between dietary fructose and diabetes that is modulated by dietary fat.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU002247 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001374 project
	SA207267 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001374 project
	SA207345 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001374 project
	SA207412 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001374 project
	SA207390 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001374 project
	SA207388 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001374 project
	SA207257 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001374 project
	SA207375 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001374 project
	SA207211 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001374 project

PPR00001

Project (Entity type)

Metabolomics

SU002247

Subject (Entity type)

A subject from Metabolomics produced as part of the PR001374 project

SA207267

Biosample (Entity type)