PR001027 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8Z41B

Description:The intrinsic aerobic capacity of an organism is thought to play a role in aging and longevity. Maximal respiratory rate capacity, a metabolic performance measure, is one of the best predictors of cardiovascular- and all-cause mortality. Rats selectively bred for high-(HCR) vs. low-(LCR) intrinsic running-endurance capacity have up to 31% longer lifespan. We found that positive changes in indices of mitochondrial health in cardiomyocytes (respiratory reserve, maximal respiratory capacity, resistance to mitochondrial permeability transition, autophagy/mitophagy, higher lipids-over-glucose utilization) are uniformly associated with the extended longevity in HCR vs. LCR female rats. Cross-sectional heart metabolomics revealed pathways from lipid metabolism in the heart which were significantly enriched by a select group of strain dependent metabolites, consistent with enhanced lipids utilization by HCR cardiomyocytes. Heart-liver-serum metabolomics further revealed shunting of lipidic substrates between liver and heart via serum during aging. Thus, mitochondrial health in cardiomyocytes is associated with extended longevity in rats with higher intrinsic exercise capacity, and likely these findings can be translated to other populations as predictors of outcomes of health and survival.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU001600 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001027 project
	SA128627 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001027 project
	SA128649 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001027 project
	SA128555 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001027 project
	SA128629 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001027 project
	SA128610 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001027 project
	SA128591 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001027 project
	SA128544 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001027 project
	SA128619 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001027 project