PR001742 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8J71N

Description:Although some progress has been made in the study of radiation injury, there are still no effective prevention and treatment methods for severe acute radiation syndrome or sickness (ARS). Accordingly, a thorough understanding of biological characteristics associated with high-dose radiation is essential for revealing the mechanisms underlying the varied biological processes following high dose radiation and the development of novel potent radioprotective agents. Therefore, in this paper, we investigated the metabolic characteristics of plasma and lung tissue of rats exposed to whole-thorax irradiation (WTI) by liquid chromatography-mass spectrometry (LC-MS). The correlation of metabolic characteristics between plasma and lung tissue of WTI rats was studied. Parallel metabolic pathway analysis of common differential metabolites suggests that the metabolic characteristics of plasma can reflect the metabolic changes of RILI. On this basis, the potential plasma biomarkers of RILI (acylcarnitine C9:1, acylcarnitine C5:0, taurocholic acid and tauro-a-Muricholic acid) were screened, and their dose-response patterns suggest that they have the potential for early diagnosis and evaluation of RILI.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU002901 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001742 project
	SA299688 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001742 project
	SA299927 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001742 project
	SA299693 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001742 project
	SA299731 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001742 project
	SA299775 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001742 project
	SA299952 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001742 project
	SA300035 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001742 project
	SA299988 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001742 project