PR002127 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20251214.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8PG19

Description:Radiation-induced liver damage (RILD) is a disease characterized by a series of physiological and pathological changes in liver tissue following exposure to a certain dose of radiation, and it is also a common complication of liver cancer and abdominal tumor radiotherapy. To date, the pathogenesis of RILD remains unclear, and effective diagnostic and therapeutic approaches are lacking. Based on this, the present study established an animal model of radiation-induced liver disease (RILD) using whole-liver irradiated rats. Metabolomics and transcriptomics were integrated to analyze liver tissue samples collected 7 days post-irradiation. The involved metabolic disorders primarily include ammonia metabolism, amino acid metabolism, glutathione metabolism and lipid metabolism. Moreover, a panel of potential plasma metabolic markers was identified through correlation analysis between liver tissue and plasma metabolic characteristics. Subsequently, the levels of radiation injury within 7 days post irradiation were assessed. This study provides experimental evidence for the identification of early diagnostic markers for whole-liver irradiation and RILD, as well as for exploring the molecular and pathophysiological mechanisms of RILD.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU003581 Subject (Entity type)	A subject from Metabolomics produced as part of the PR002127 project
	ST003453 Rawfiles.zip File (Entity type)	A 1.72 GB file from Metabolomics produced from OBI:0000470 as part of the PR002127 project
	SA381702 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002127 project
	SA381585 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002127 project
	SA381653 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002127 project
	SA381670 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002127 project
	SA381593 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002127 project
	SA381961 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002127 project
	SA381561 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002127 project