Description:In this study, an IgE-mediated RBL-2H3 cell degranulation model was firstly developed. Then, ultra-high-performance liquid chromatography coupled to mass spectrometry (UPLC-MS) was used to perform the non-targeted lipidomics study, in order to investigate the effects and mechanism of curcumin/EGCG on IgE-mediated RBL-2H3 cells degranulation.