PR000313 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20251214.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8QG7W

Description:Metformin, a biguanide molecule, which is used as first line therapy for type 2 diabetes. In this study, we would like to investigate the inhibition of an enzyme called diamine oxidase (DAO) (also known as ABP1), by metformin. Based on our preliminary in vitro study using diamine oxidase enzyme, we saw increased level of putrescine with increasing metformin concentrations (see reference PMID: 26335661). This proposed in vivo study was to determine whether metformin could increase putrescine levels and other metabolites in mice. Aminoguanidine, a known inhibitor of DAO, in this study as positive control, following similar study design described in this paper (PMID: 8912017).

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU000422 Subject (Entity type)	A subject from Metabolomics produced as part of the PR000313 project
	ST000401.zip File (Entity type)	A 326 MB file from Metabolomics produced from OBI:0003110 as part of the PR000313 project
	SA019231 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000313 project
	SA019248 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000313 project
	SA019224 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000313 project
	SA019239 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000313 project
	SA019230 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000313 project
	SA019225 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000313 project
	SA019250 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000313 project

PPR00001

Project (Entity type)

Metabolomics

SU000422

Subject (Entity type)

A subject from Metabolomics produced as part of the PR000313 project

ST000401.zip

File (Entity type)

A 326 MB file from Metabolomics produced from OBI:0003110 as part of the PR000313 project

SA019231

Biosample (Entity type)