PR000410 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M82889

Description:Diabetic nephropathy (DN) is the leading cause of end stage renal disease, and is associated with high morbidity and mortality rates. The pathophysiology of DN includes both glomerular and tubulointerstitial damage. Meprins are metalloproteinases which are most abundantly expressed in the brush border membranes of proximal kidney tubules. Meprins are also expressed in leukocytes (monocytes and macrophages) and podocytes. Meprins have been implicated in the pathology of acute and chronic kidney injury. Single nucleotide polymorphisms (SNPs) in the meprin ß gene were associated in human DN in the Pima Indians, suggesting a role for meprins in the pathophysiology of DN. The current study was done to determine the mechanisms by which meprins modulate the progression of DN in mice.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU000581 Subject (Entity type)	A subject from Metabolomics produced as part of the PR000410 project
	SA028867 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000410 project
	SA028848 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000410 project
	SA028846 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000410 project
	SA028866 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000410 project
	SA028859 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000410 project
	SA028869 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000410 project
	SA028879 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000410 project
	SA028872 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR000410 project

PPR00001

Project (Entity type)

Metabolomics

SU000581

Subject (Entity type)

A subject from Metabolomics produced as part of the PR000410 project

SA028867

Biosample (Entity type)