PR001761 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M83139

Description:Mounting evidence supports an instructive role for metabolism in stem cell fate decisions. However, much is yet unknown about how fetal metabolism changes during mammalian development and how altered maternal metabolism shapes fetal metabolism. Here, we present a descriptive atlas of in vivo fetal murine metabolism during mid-to-late gestation in normal and diabetic pregnancy. Using 13C-glucose and LC-MS, we profiled the metabolism of fetal brains, hearts, livers, and placentas harvested from pregnant dams between embryonic days (E)10.5 and 18.5. Comparative analysis of our large metabolomics dataset revealed metabolic features specific to fetal tissues developed under a hyperglycemic environment as well as metabolic signatures that may denote developmental transitions during euglycemic development. We observed sorbitol accumulation in fetal tissues and altered neurotransmitter levels in fetal brains isolated from dams with maternal hyperglycemia. Tracing 13C-glucose revealed disparate nutrient sourcing in fetuses depending on maternal glycemic states. Regardless of glycemic state, histidine-derived metabolites accumulated during late development in fetal tissues and maternal plasma. Our rich dataset presents a comprehensive overview of in vivo fetal tissue metabolism and alterations occurring as a result of maternal hyperglycemia.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU002983 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001761 project
	SU002991 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001761 project
	SA313404 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001761 project
	SA314517 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001761 project
	SA314560 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001761 project
	SA313279 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001761 project
	SA313524 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001761 project
	SA314666 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001761 project
	SA313463 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001761 project