PR001908 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M83720

Description:Psoriasis is an immune-mediated and chronic inflammatory skin disease Previous research on exploring psoriasis biomarkers using metabolomics lacks a validation step. Moreover, short peptide information in these studies was not investigated. Here, we conducted a comprehensive HILIC-HRMS-based plasma metabolomics study on different population sets, including healthy controls, psoriasis, and urticaria patients. With the aim of identifying potential biomarkers specific to psoriasis, the study design included a discovery step, a validation step, and a further refinement step using urticaria samples. We identified 9 potential biomarkers specific to psoriasis, with 5 being structurally characterized. Two dipeptide biomarkers, γ-GluSer and ThrGly, along with a lysine glycation metabolite, Fruc-Lys, were found to be associated with psoriasis for the first time. Receiver operating characteristic curve analysis revealed all these 9 biomarkers with AUC values above 0.80. A biomarker panel comprising ThrGly and Fruc-Lys demonstrated high diagnostic accuracy (AUC=0.95) in distinguishing psoriasis patients from healthy controls.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU003177 Subject (Entity type)	A subject from Metabolomics produced as part of the PR001908 project
	SA331939 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001908 project
	SA331936 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001908 project
	SA331918 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001908 project
	SA331906 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001908 project
	SA331883 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001908 project
	SA331909 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001908 project
	SA331872 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001908 project
	SA331923 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001908 project