SHMT2 (Gene)

Description: serine hydroxymethyltransferase 2

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SHMT2's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SHMT2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SHMT2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SHMT2.

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Gene Sets (738)

LINCS L1000 Chem Pert Consensus Sigs (563)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (5)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (10)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (155)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (1)

A gene set library provided by MoTrPAC

IDG Drug Targets 2022 (4)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
Doxycycline Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SHMT2 Gene (Entity type)	0.0030764393
3-[9-Fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl]-4-imidazo[1,2-a]pyridin-3-yl-pyrrole-2,5-dione Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SHMT2 Gene (Entity type)	0.014240084
SID11111867 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SHMT2 Gene (Entity type)	0.012073471
phloretin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SHMT2 Gene (Entity type)	0.007005575
KFGENEBIN:SHMT2-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	SHMT2 Gene (Entity type)
venetoclax Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SHMT2 Gene (Entity type)	0.0045273947
Ponatinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SHMT2 Gene (Entity type)	0.008620188
(+/-)-Gossypol Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SHMT2 Gene (Entity type)	0.0073010353
Erlotinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SHMT2 Gene (Entity type)	0.00446886
Erastin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SHMT2 Gene (Entity type)	0.003997735