IRS1 (Gene)

Description: insulin receptor substrate 1

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View IRS1's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with IRS1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using IRS1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for IRS1.

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Gene Sets (1592)

LINCS L1000 Chem Pert Consensus Sigs (797)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (2)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (1)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (790)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (2)

A gene set library provided by MoTrPAC

Knowledge Graph Assertions

Source	Relation	Target	Evidence
SID88095706 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IRS1 Gene (Entity type)	0.0135735525
ranitidine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IRS1 Gene (Entity type)	-0.0033025073
AZD7545 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IRS1 Gene (Entity type)	0.0029728403
SA-1459854 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IRS1 Gene (Entity type)	0.012332882
SID11114027 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IRS1 Gene (Entity type)	0.00812904
flavanone Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IRS1 Gene (Entity type)	-0.009712186
Ki16425 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IRS1 Gene (Entity type)	0.010697049
Moxonidine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IRS1 Gene (Entity type)	-0.0034140274
(E)-2-(4-(4-fluorophenoxy)benzylidene)hydrazinecarboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IRS1 Gene (Entity type)	-0.0042905896
(1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl)-phosphonic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	IRS1 Gene (Entity type)	0.005570848