PBX1 (Gene)

Organism:

Homo sapiens

Synonyms:CAKUHED, ENTREZ:5087, HGNC:8632, MIM:176310, NM_001204961, NM_001204963, NM_001353130, NM_001353131, NM_002585, NP_001191890, NP_001191892, NP_001340059, NP_001340060, NP_002576, PBX homeobox 1, PBX1, XM_005245228, XM_005245229, XM_011509590, XM_011509591, XM_011509592, XM_017001395, XP_005245285, XP_005245286, XP_011507892, XP_011507893, XP_011507894, XP_016856884

Omim:OMIM:176310

Id:ENSG00000185630

Hgnc:HGNC:8632

Entrez:5087

Ensembl:ENSG00000185630

Description:PBX homeobox 1

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PBX1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PBX1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PBX1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PBX1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PBX1.

Results found

Linked to

	Label	Description
	GSE214505 AKR1B1 knockdown A-549 3 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE218097 SOX10 overexpression glial cell 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE233647 docetaxel UFERSA-PC3 DU145 4 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE115542 digoxin 5 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE214505 AKR1B1 knockdown A-549 3 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE193993 SSTR2 knockout 0 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE199859 A-7 HCA7 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE133933 fibulin-3 knockdown 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE119978 GSE180930 cisplatin 3 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE233647 docetaxel UFERSA-PC3 DU145 2 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE214505 AKR1B1 knockdown A-549 3 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE218097 SOX10 overexpression glial cell 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE233647 docetaxel UFERSA-PC3 DU145 4 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE115542 digoxin 5 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE214505 AKR1B1 knockdown A-549 3 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE193993 SSTR2 knockout 0 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE199859 A-7 HCA7 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE133933 fibulin-3 knockdown 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE119978 GSE180930 cisplatin 3 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE233647 docetaxel UFERSA-PC3 DU145 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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