FOXO4 (Gene)

Entrez Gene ID: 4303

Description: forkhead box O4

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View FOXO4's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with FOXO4.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using FOXO4.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for FOXO4.

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Gene Sets (1014)

LINCS L1000 Chem Pert Consensus Sigs (413)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (7)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (4)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (47)

A gene set library provided by LINCS

rummageo gene perturbations (144)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (203)

A gene set library provided by LINCS

rummageo chemical perturbations (187)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (7)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (2)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
2-(1H-Indazol-4-yl)-6-(4-methanesul fonyl-piperazin-1-ylmethyl)-4-morph olin-4-yl-thieno[3,2-d]pyrimidine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	FOXO4 Gene (Entity type)	0.005511634
2-[[5-Chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]-amino]pyrimidin-4-yl]amino]-N-methylbenzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	FOXO4 Gene (Entity type)	0.0052625495
AZD3463 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	FOXO4 Gene (Entity type)	0.013543113
3-(4-(((2-(1H-indol-3-yl)ethyl)(2-hydroxyethyl)amino)methyl)phenyl)-N-hydroxyacrylamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	FOXO4 Gene (Entity type)	0.010350348
SAR-245408 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FOXO4 Gene (Entity type)	-0.0040226886
latrunculin-b Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	FOXO4 Gene (Entity type)	0.016086275
Vorinostat Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	FOXO4 Gene (Entity type)	0.012789503
BMS-754807 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	FOXO4 Gene (Entity type)	0.011866858
3-(1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(phenylamino)-1H-pyrrole-2,5-dione Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FOXO4 Gene (Entity type)	-0.010686799
AZD5438 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FOXO4 Gene (Entity type)	-0.010001399

2-(1H-Indazol-4-yl)-6-(4-methanesul fonyl-piperazin-1-ylmethyl)-4-morph olin-4-yl-thieno[3,2-d]pyrimidine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
FOXO4
Gene (Entity type)
0.005511634

2-[[5-Chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]-amino]pyrimidin-4-yl]amino]-N-methylbenzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
FOXO4
Gene (Entity type)
0.0052625495

AZD3463
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
FOXO4
Gene (Entity type)
0.013543113

3-(4-(((2-(1H-indol-3-yl)ethyl)(2-hydroxyethyl)amino)methyl)phenyl)-N-hydroxyacrylamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
FOXO4
Gene (Entity type)
0.010350348

SAR-245408
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FOXO4
Gene (Entity type)
-0.0040226886

latrunculin-b
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
FOXO4
Gene (Entity type)
0.016086275

Vorinostat
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
FOXO4
Gene (Entity type)
0.012789503

BMS-754807
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
FOXO4
Gene (Entity type)
0.011866858

3-(1-(3-(1H-imidazol-1-yl)propyl)-1H-indol-3-yl)-4-(phenylamino)-1H-pyrrole-2,5-dione
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FOXO4
Gene (Entity type)
-0.010686799

AZD5438
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FOXO4
Gene (Entity type)
-0.010001399

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.