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CFDE Workbench

PLA2G6 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CaI-PLA2, ENTREZ:8398, GVI, HGNC:9039, INAD1, IPLA2-VIA, MIM:603604, NBIA2, NBIA2A, NBIA2B, NM_001004426, NM_001199562, NM_001349864, NM_001349865, NM_001349866, NM_001349867, NM_001349868, NM_001349869, NM_003560, NP_001004426, NP_001186491, NP_001336793, NP_001336794, NP_001336795, NP_001336796, NP_001336797, NP_001336798, NP_003551, PARK14, PLA2, PLA2G6, PNPLA9, iPLA2, iPLA2beta, phospholipase A2 group VI
Omim:OMIM:603604
Id:ENSG00000184381
Hgnc:HGNC:9039
Entrez:8398
Ensembl:ENSG00000184381
Description:phospholipase A2 group VI
The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PLA2G6's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PLA2G6.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PLA2G6.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PLA2G6.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PLA2G6.

Results found

Linked to

 

Label

Description

 

Phenotype

Ataxia

Phenotype (Entity type)

Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...

Gene Set

GSE77829 SLIRP knockdown LNCaP 3 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE128730 neratinib OVCAR-8 7 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE115384 CELSR2 knockdown 2 v 7 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE183041 cisplatin 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE128099 GSE128159 gemcitabine SUM159PT 3 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE208350 H-7 Huh-7 JHH-7 0 v 8 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE261563 CX-5461 2 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE115384 CELSR2 knockdown 6 v 7 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE201309 matrine 1 v 6 human up

Gene Set (Entity type)

A Gene Set from LINCS

  • Phenotype

    Ataxia

    Phenotype (Entity type)

    Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...

  • Gene Set

    GSE77829 SLIRP knockdown LNCaP 3 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE128730 neratinib OVCAR-8 7 v 2 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE115384 CELSR2 knockdown 2 v 7 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE183041 cisplatin 1 v 0 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE128099 GSE128159 gemcitabine SUM159PT 3 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE208350 H-7 Huh-7 JHH-7 0 v 8 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE261563 CX-5461 2 v 4 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE115384 CELSR2 knockdown 6 v 7 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE201309 matrine 1 v 6 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

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    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.