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CFDE Workbench

TCIM (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:C8orf4, ENTREZ:56892, HGNC:1357, MIM:607702, NM_020130, NP_064515, TC-1, TC1, TCIM, transcriptional and immune response regulator
Omim:OMIM:607702
Id:ENSG00000176907
Hgnc:HGNC:1357
Entrez:56892
Ensembl:ENSG00000176907
Description:transcriptional and immune response regulator
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TCIM's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with TCIM.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TCIM.

Submit
Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TCIM.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TCIM.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE214505 AKR1B1 knockdown A-549 3 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE218097 SOX10 overexpression glial cell 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE199859 A-7 HCA7 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE238213 dopamine 5 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE77108 saha 4 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE108464 AZ-628 6 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE133749 BMPR2 overexpression endothelial cell 0 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE206931 WDR5 inhibition WIN 8 v 7 human up

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE214505 AKR1B1 knockdown A-549 3 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE218097 SOX10 overexpression glial cell 2 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE199859 A-7 HCA7 1 v 2 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE238213 dopamine 5 v 3 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE77108 saha 4 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE108464 AZ-628 6 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE133749 BMPR2 overexpression endothelial cell 0 v 4 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE206931 WDR5 inhibition WIN 8 v 7 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.