CDK5R1 (Gene)

Organism:

Homo sapiens

Synonyms:CDK5P35, CDK5R, CDK5R1, ENTREZ:8851, HGNC:1775, MIM:603460, NCK5A, NM_003885, NP_003876, XM_011525438, XM_017025281, XP_011523740, XP_016880770, cyclin dependent kinase 5 regulatory subunit 1, p23, p25, p35, p35nck5a

Omim:OMIM:603460

Id:ENSG00000176749

Hgnc:HGNC:1775

Entrez:8851

Ensembl:ENSG00000176749

Description:cyclin dependent kinase 5 regulatory subunit 1

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CDK5R1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CDK5R1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CDK5R1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CDK5R1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CDK5R1.

Results found

Linked to

	Label	Description
	GSE115542 digoxin 5 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE254526 GSE254528 MI-1 Kasumi-1 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE117805 A-66 3 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE74251 decitabine MCF-7 2 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE213588 trametinib NF1 10 v 5 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE214306 CCM1 knockout 5 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE209582 fluorouracil 1 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE115542 5 V 1 DIGOXIN HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE143944 1 V 0 RIBOCICLIB HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE153871 cytarabine U2OS 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS

GSE115542 digoxin 5 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE254526 GSE254528 MI-1 Kasumi-1 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE117805 A-66 3 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE74251 decitabine MCF-7 2 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE213588 trametinib NF1 10 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE214306 CCM1 knockout 5 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE209582 fluorouracil 1 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE115542 5 V 1 DIGOXIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE143944 1 V 0 RIBOCICLIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE153871 cytarabine U2OS 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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