ORAI3 (Gene)

Entrez Gene ID: 93129

Description: ORAI calcium release-activated calcium modulator 3

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View ORAI3's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with ORAI3.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using ORAI3.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for ORAI3.

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Gene Sets (961)

LINCS L1000 Chem Pert Consensus Sigs (323)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (3)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (1)

A gene set library provided by GlyGen

KOMP2 Mouse Phenotypes 2022 (1)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (76)

A gene set library provided by LINCS

rummageo gene perturbations (164)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (153)

A gene set library provided by LINCS

rummageo chemical perturbations (240)

A gene set library provided by LINCS

Knowledge Graph Assertions

Source	Relation	Target	Evidence
wortmannin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ORAI3 Gene (Entity type)	0.005626963
PP-110 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ORAI3 Gene (Entity type)	0.011532755
BMS-345541 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ORAI3 Gene (Entity type)	-0.0050114114
4-[(S)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-3-(4-methyl-6-morpholin-4-yl-1H-benzoimidazol-2-yl)-1H-pyridin-2-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ORAI3 Gene (Entity type)	0.0069215223
TAK-733 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ORAI3 Gene (Entity type)	0.010736657
N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ORAI3 Gene (Entity type)	-0.003770589
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ORAI3 Gene (Entity type)	0.005757426
PP-30 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ORAI3 Gene (Entity type)	0.011207423
Efatutazone Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ORAI3 Gene (Entity type)	-0.007332047
KFGENEBIN:ORAI3-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	ORAI3 Gene (Entity type)

wortmannin
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ORAI3
Gene (Entity type)
0.005626963

PP-110
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ORAI3
Gene (Entity type)
0.011532755

BMS-345541
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ORAI3
Gene (Entity type)
-0.0050114114

4-[(S)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-3-(4-methyl-6-morpholin-4-yl-1H-benzoimidazol-2-yl)-1H-pyridin-2-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ORAI3
Gene (Entity type)
0.0069215223

TAK-733
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ORAI3
Gene (Entity type)
0.010736657

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ORAI3
Gene (Entity type)
-0.003770589

1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ORAI3
Gene (Entity type)
0.005757426

PP-30
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ORAI3
Gene (Entity type)
0.011207423

Efatutazone
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ORAI3
Gene (Entity type)
-0.007332047

KFGENEBIN:ORAI3-variant-count CUI
KFGENEBIN (Entity type)
Gene has variants
Knowledge Graph Relation (Entity type)
ORAI3
Gene (Entity type)

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.