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CFDE Workbench

CD8B (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CD8B, CD8B1, CD8b molecule, ENTREZ:926, HGNC:1707, LEU2, LY3, LYT3, MIM:186730, NM_001178100, NM_004931, NM_172099, NM_172101, NM_172102, NM_172213, NP_001171571, NP_004922, NP_742099, NP_742100, NP_757362, P37, XM_011533164, XP_011531466
Omim:OMIM:186730
Nci:C21371
Id:ENSG00000172116
Hgnc:HGNC:1707
Entrez:926
Ensembl:ENSG00000172116
Description:CD8 subunit beta
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CD8B's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CD8B.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CD8B.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CD8B.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CD8B.

Results found

Linked to

 

Label

Description

 

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T60-Adrenal Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

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GSE214306 CCM1 knockout 5 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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GSE238213 dopamine 2 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE135350 XPO1 inhibition Dexamethasone 3 v 6 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE135350 dexamethasone 3 v 6 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE225375 CDK12 CDK13 inhibition 1 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE95077 amiloride 5 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE149768 hypoxanthine 3 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE114492 GSE153671 KMT2D inhibition 10 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE203329 HCC knockout 0 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    T60-Adrenal Consensus

    Gene Set (Entity type)

    A Gene Set from MoTrPAC

  • Gene Set

    GSE214306 CCM1 knockout 5 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE238213 dopamine 2 v 4 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE135350 XPO1 inhibition Dexamethasone 3 v 6 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE135350 dexamethasone 3 v 6 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE225375 CDK12 CDK13 inhibition 1 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE95077 amiloride 5 v 4 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE149768 hypoxanthine 3 v 4 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE114492 GSE153671 KMT2D inhibition 10 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE203329 HCC knockout 0 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.