PKIA (Gene)

Entrez Gene ID: 5569

Description: cAMP-dependent protein kinase inhibitor alpha

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PKIA's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PKIA.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PKIA.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PKIA.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PKIA.

Gene Sets (2825)

LINCS L1000 Chem Pert Consensus Sigs (553)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (25)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (1)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (548)

A gene set library provided by LINCS

rummageo gene perturbations (222)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (8)

A gene set library provided by GTEx

RummaGEO DrugPerturbations 2025 (380)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (795)

A gene set library provided by LINCS

rummageo chemical perturbations (290)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (3)

A gene set library provided by MoTrPAC

Knowledge Graph Assertions

Source	Relation	Target	Evidence
fenthion Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PKIA Gene (Entity type)	0.0058433935
KU-C104132 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PKIA Gene (Entity type)	-0.011705778
10H-Phenoxazine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PKIA Gene (Entity type)	0.006947632
SID11112839 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PKIA Gene (Entity type)	0.003557776
Azauridine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PKIA Gene (Entity type)	0.009679814
EMF-sumo1-6 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PKIA Gene (Entity type)	0.010239736
hydrocortisone-hemisuccinate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PKIA Gene (Entity type)	-0.01104432
SID11113467 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PKIA Gene (Entity type)	0.0076942327
hydrocortisone-acetate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PKIA Gene (Entity type)	-0.013550347
CCMQ Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PKIA Gene (Entity type)	0.012053267

fenthion
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PKIA
Gene (Entity type)
0.0058433935

KU-C104132
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PKIA
Gene (Entity type)
-0.011705778

10H-Phenoxazine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PKIA
Gene (Entity type)
0.006947632

SID11112839
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PKIA
Gene (Entity type)
0.003557776

Azauridine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PKIA
Gene (Entity type)
0.009679814

EMF-sumo1-6
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PKIA
Gene (Entity type)
0.010239736

hydrocortisone-hemisuccinate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PKIA
Gene (Entity type)
-0.01104432

SID11113467
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PKIA
Gene (Entity type)
0.0076942327

hydrocortisone-acetate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PKIA
Gene (Entity type)
-0.013550347

CCMQ
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PKIA
Gene (Entity type)
0.012053267

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.