UPF3A (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:65110, HGNC:20332, HUPF3A, MIM:605530, NM_001353644, NM_001353645, NM_001353646, NM_001353647, NM_001353648, NM_001353649, NM_001353650, NM_001353651, NM_001353652, NM_023011, NM_080687, NP_001340573, NP_001340574, NP_001340575, NP_001340576, NP_001340577, NP_001340578, NP_001340579, NP_001340580, NP_001340581, NP_075387, NP_542418, NR_148482, NR_148483, NR_148484, NR_148485, NR_148486, NR_148487, NR_148488, NR_148489, NR_148490, NR_148491, NR_148492, NR_148493, NR_148494, NR_148495, NR_148496, RENT3A, UPF3, UPF3A regulator of nonsense mediated mRNA decay, UPF3A, XM_005266202, XM_006719991, XM_011534844, XM_011534845, XM_011534846, XM_011534847, XM_011534848, XM_017020709, XM_017020711, XM_024449400, XM_024449401, XM_024449402, XM_024449403, XP_005266259, XP_006720054, XP_011533146, XP_011533147, XP_011533148, XP_011533149, XP_011533150, XP_016876198, XP_016876200, XP_024305168, XP_024305169, XP_024305170, XP_024305171, XR_001749644, XR_001749646, XR_001749647, XR_001749649, XR_941422

Omim:OMIM:605530

Id:ENSG00000169062

Hgnc:HGNC:20332

Entrez:65110

Ensembl:ENSG00000169062

Description:UPF3A regulator of nonsense mediated mRNA decay

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

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CFDE DD-Knowledge Graph

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Playbook Workflow Builder: Gene-Centric Workflow

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CFDE Gene-Centric Appyter

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for UPF3A.

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Playbook Workflow Builder

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Results found

Linked to

	Label	Description
	GSE179112 GSE179113 hydroxyl Hutt45 4 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE118548 trametinib T84 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE218097 SOX10 overexpression glial cell 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE233647 docetaxel UFERSA-PC3 DU145 4 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE182680 GSE182683 dexamethasone 10 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE252944 AKT inhibition 7 v 9 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE153871 cytarabine U2OS 4 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE193993 SSTR2 knockout 0 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS

GSE179112 GSE179113 hydroxyl Hutt45 4 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE118548 trametinib T84 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE218097 SOX10 overexpression glial cell 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE233647 docetaxel UFERSA-PC3 DU145 4 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE182680 GSE182683 dexamethasone 10 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE252944 AKT inhibition 7 v 9 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE153871 cytarabine U2OS 4 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE193993 SSTR2 knockout 0 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

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CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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