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CFDE Workbench

CYBB (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:AMCBX2, CGD, CYBB, ENTREZ:1536, GP91-1, GP91-PHOX, GP91PHOX, HGNC:2578, IMD34, MIM:300481, NM_000397, NOX2, NP_000388, cytochrome b-245 beta chain, p91-PHOX
Omim:OMIM:300481
Id:ENSG00000165168
Hgnc:HGNC:2578
Entrez:1536
Ensembl:ENSG00000165168
Description:cytochrome b-245 beta chain
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]

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Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CYBB's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CYBB.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CYBB.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CYBB.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CYBB.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE190937 AHCY MAT2A knockout Rael 4 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Phenotype

Ataxia

Phenotype (Entity type)

Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...

Gene Set

GSE108464 AZ-628 1 v 9 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE48812 sulforaphane 4 v 10 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE159209 artemisinin stem cell 3 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE191005 ENL knockout MOLM-13 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE239688 canagliflozin 4 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE116810 5 V 4 SELINEXOR HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE119978 GSE180930 cisplatin 3 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE120612 etoposide leukocyte 4 v 5 human up

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE190937 AHCY MAT2A knockout Rael 4 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Phenotype

    Ataxia

    Phenotype (Entity type)

    Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...

  • Gene Set

    GSE108464 AZ-628 1 v 9 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE48812 sulforaphane 4 v 10 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE159209 artemisinin stem cell 3 v 4 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE191005 ENL knockout MOLM-13 1 v 0 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE239688 canagliflozin 4 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE116810 5 V 4 SELINEXOR HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE119978 GSE180930 cisplatin 3 v 5 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE120612 etoposide leukocyte 4 v 5 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.