CGAS (Gene)

Organism:

Homo sapiens

Synonyms:C6orf150, CGAS, ENTREZ:115004, HGNC:21367, MB21D1, MIM:613973, NM_138441, NP_612450, cyclic GMP-AMP synthase, h-cGAS

Omim:OMIM:613973

Id:ENSG00000164430

Hgnc:HGNC:21367

Entrez:115004

Ensembl:ENSG00000164430

Description:cyclic GMP-AMP synthase

Enables several functions, including 2',3'-cyclic GMP-AMP synthase activity; chromatin binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of defense response. Located in several cellular components, including cytosol; nucleus; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CGAS's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CGAS.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CGAS.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CGAS.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CGAS.

Results found

Linked to

	Label	Description
	GSE171837 bortezomib 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE142588 cinobufagin 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE99875 everolimus 2 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE239844 crizotinib 11 v 9 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE176008 pyridoxine 4 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE213588 trametinib NF1 8 v 7 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE213588 trametinib NF1 8 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE171837 0 V 1 BORTEZOMIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE153867 olaparib 6 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE179112 GSE179113 hydroxyl Hutt45 4 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE171837 bortezomib 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE142588 cinobufagin 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE99875 everolimus 2 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE239844 crizotinib 11 v 9 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE176008 pyridoxine 4 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE213588 trametinib NF1 8 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE213588 trametinib NF1 8 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE171837 0 V 1 BORTEZOMIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE153867 olaparib 6 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE179112 GSE179113 hydroxyl Hutt45 4 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.