PTPN13 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:5783, FAP-1, HGNC:9646, MIM:600267, NM_006264, NM_080683, NM_080684, NM_080685, NP_006255, NP_542414, NP_542415, NP_542416, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, PTPN13, XM_011532165, XM_017008511, XM_017008512, XM_017008513, XM_017008514, XM_017008515, XM_017008516, XP_011530467, XP_016864000, XP_016864001, XP_016864002, XP_016864003, XP_016864004, XP_016864005, hPTP1E, protein tyrosine phosphatase non-receptor type 13

Omim:OMIM:600267

Nci:C104212

Id:ENSG00000163629

Hgnc:HGNC:9646

Entrez:5783

Ensembl:ENSG00000163629

Description:protein tyrosine phosphatase non-receptor type 13

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PTPN13's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PTPN13.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PTPN13.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PTPN13.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PTPN13.

Results found

Linked to

	Label	Description
	T61-Colon Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE118548 trametinib T84 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE226525 GSE226527 HNRNPH2 knockout 4 v 8 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE228619 cadherin-11 CDH11 knockdown RNA Small Interfering 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE213588 trametinib NF1 8 v 7 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE164874 prednisolone muscle organ 5 v 9 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE118548 1 V 2 TRAMETINIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE184892 trehalose fibroblast 4 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS

T61-Colon Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

GSE118548 trametinib T84 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE226525 GSE226527 HNRNPH2 knockout 4 v 8 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE228619 cadherin-11 CDH11 knockdown RNA Small Interfering 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE213588 trametinib NF1 8 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE164874 prednisolone muscle organ 5 v 9 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE118548 1 V 2 TRAMETINIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE184892 trehalose fibroblast 4 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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