CLDN1 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)

Synonyms:CLD1, CLDN1, ENTREZ:9076, HGNC:2032, ILVASC, MIM:603718, NM_021101, NP_066924, SEMP1, claudin 1

Omim:OMIM:603718

Id:ENSG00000163347

Hgnc:HGNC:2032

Entrez:9076

Ensembl:ENSG00000163347

Description:claudin 1

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CLDN1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CLDN1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CLDN1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CLDN1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CLDN1.

Results found

Linked to

	Label	Description
	T60-Adrenal Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	T61-Colon Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE158834 ADIPOR2 knockout HEK293 7 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE158834 7 V 3 PALMITIC ACID HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE99875 everolimus 2 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE133933 fibulin-3 knockdown 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE193993 SSTR2 knockout 4 v 7 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE119978 GSE180930 cisplatin 3 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE193993 SSTR2 knockout 1 v 7 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE235701 GSE261434 enasidenib 2 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS

T60-Adrenal Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

T61-Colon Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

GSE158834 ADIPOR2 knockout HEK293 7 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE158834 7 V 3 PALMITIC ACID HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE99875 everolimus 2 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE133933 fibulin-3 knockdown 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE193993 SSTR2 knockout 4 v 7 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE119978 GSE180930 cisplatin 3 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE193993 SSTR2 knockout 1 v 7 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE235701 GSE261434 enasidenib 2 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

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Community

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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