CYP3A4 (Gene)

Organism:

Homo sapiens

Synonyms:CP33, CP34, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, ENTREZ:1576, HGNC:2637, HLP, MIM:124010, NF-25, NM_001202855, NM_001202856, NM_001202857, NM_017460, NP_001189784, NP_059488, P450C3, P450PCN1, VDDR3, cytochrome P450 family 3 subfamily A member 4

Omim:OMIM:124010

Id:ENSG00000160868

Hgnc:HGNC:2637

Entrez:1576

Ensembl:ENSG00000160868

Description:cytochrome P450 family 3 subfamily A member 4

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CYP3A4's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CYP3A4.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CYP3A4.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CYP3A4.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CYP3A4.

Results found

Linked to

	Label	Description
	GSE190178 MEK CDK8 inhibition 3 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE114492 GSE153671 KMT2D inhibition 6 v 11 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE129698 SYK inhibition 6 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE157036,GSE166411 3 V 1 HALOFUGINONE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE213650 everolimus 3 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE226525 GSE226527 HNRNPH2 knockout 4 v 5 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE213650 3 V 1 EVEROLIMUS HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE120229 PCIF1 knockdown 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE220283 STAT3 knockdown Hep-G2 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE197571 FOXM1 RNF112 overexpression MGC-803 3 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS

GSE190178 MEK CDK8 inhibition 3 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE114492 GSE153671 KMT2D inhibition 6 v 11 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE129698 SYK inhibition 6 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE157036,GSE166411 3 V 1 HALOFUGINONE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE213650 everolimus 3 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE226525 GSE226527 HNRNPH2 knockout 4 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE213650 3 V 1 EVEROLIMUS HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE120229 PCIF1 knockdown 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE220283 STAT3 knockdown Hep-G2 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE197571 FOXM1 RNF112 overexpression MGC-803 3 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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