CLDN8 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)

Synonyms:CLDN8, ENTREZ:9073, HEL-S-79, HGNC:2050, MIM:611231, NM_012132, NM_199328, NP_955360, claudin 8

Omim:OMIM:611231

Id:ENSG00000156284

Hgnc:HGNC:2050

Entrez:9073

Ensembl:ENSG00000156284

Description:claudin 8

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CLDN8's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CLDN8.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CLDN8.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CLDN8.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CLDN8.

Results found

Linked to

	Label	Description
	T61-Colon Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE252944 AKT inhibition 7 v 9 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE135514 dasatinib 8 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE158969 1 V 0 TRASTUZUMAB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE80802 EGFR inhibition Tankyrases 0 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE202434 GSE202438 talazoparib 4 v 14 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE135514 8 V 0 DASATINIB HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE135514 dasatinib 2 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE252944 AKT inhibition 3 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE220097 enzalutamide LNCaP 4 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS

T61-Colon Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

GSE252944 AKT inhibition 7 v 9 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE135514 dasatinib 8 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE158969 1 V 0 TRASTUZUMAB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE80802 EGFR inhibition Tankyrases 0 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE202434 GSE202438 talazoparib 4 v 14 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE135514 8 V 0 DASATINIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE135514 dasatinib 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE252944 AKT inhibition 3 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE220097 enzalutamide LNCaP 4 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.