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CFDE Workbench

CYP1A2 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CP12, CYP1A2, CYPIA2, ENTREZ:1544, HGNC:2596, MIM:124060, NM_000761, NP_000752, P3-450, P450(PA), cytochrome P450 family 1 subfamily A member 2
Omim:OMIM:124060
Id:ENSG00000140505
Hgnc:HGNC:2596
Entrez:1544
Ensembl:ENSG00000140505
Description:cytochrome P450 family 1 subfamily A member 2
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CYP1A2's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CYP1A2.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CYP1A2.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CYP1A2.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CYP1A2.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE143944 1 V 0 RIBOCICLIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE158969 1 V 0 TRASTUZUMAB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE48812 9 V 5 SULFORAPHANE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE193258,GSE193259 9 V 13 OSIMERTINIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE119345 bexarotene T cell 2 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE228263 FDX1 overexpression SU-DHL-4 Elesclomol 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE228263 elesclomol SU-DHL-4 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE118548 trametinib T84 1 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE195559 NOTCH1 knockout endothelial cell cardiac muscle cell stem cell 6 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE163240 enzalutamide 3 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE143944 1 V 0 RIBOCICLIB HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE158969 1 V 0 TRASTUZUMAB HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE48812 9 V 5 SULFORAPHANE HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE193258,GSE193259 9 V 13 OSIMERTINIB HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE119345 bexarotene T cell 2 v 3 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE228263 FDX1 overexpression SU-DHL-4 Elesclomol 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE228263 elesclomol SU-DHL-4 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE118548 trametinib T84 1 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE195559 NOTCH1 knockout endothelial cell cardiac muscle cell stem cell 6 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE163240 enzalutamide 3 v 4 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.