CYP1A1 (Gene)

Organism:

Homo sapiens

Synonyms:AHH, AHRR, CP11, CYP1, CYP1A1, CYPIA1, ENTREZ:1543, HGNC:2595, MIM:108330, NM_000499, NM_001319216, NM_001319217, NP_000490, NP_001306145, NP_001306146, P1-450, P450-C, P450DX, cytochrome P450 family 1 subfamily A member 1

Omim:OMIM:108330

Id:ENSG00000140465

Hgnc:HGNC:2595

Entrez:1543

Ensembl:ENSG00000140465

Description:cytochrome P450 family 1 subfamily A member 1

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CYP1A1's neighborhood in the knowledge graph.

Submit

Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CYP1A1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CYP1A1.

Submit

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CYP1A1.

Submit

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CYP1A1.

Results found

Linked to

	Label	Description
	GSE118548 trametinib T84 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE99875 everolimus 2 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE118548 1 V 2 TRAMETINIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE119424 GSE120214 TBXT brachyury inhibition 7 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE214306 CCM1 knockout 4 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE156648 DOT1L overexpression IMR-90 2 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE153867 olaparib 6 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE236280 panobinostat 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE128730 neratinib OVCAR-8 7 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE156761 dopamine neuron 0 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE118548 trametinib T84 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE99875 everolimus 2 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE118548 1 V 2 TRAMETINIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE119424 GSE120214 TBXT brachyury inhibition 7 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE214306 CCM1 knockout 4 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE156648 DOT1L overexpression IMR-90 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE153867 olaparib 6 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE236280 panobinostat 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE128730 neratinib OVCAR-8 7 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE156761 dopamine neuron 0 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.