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CFDE Workbench

HERC6 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:ENTREZ:55008, HECT and RLD domain containing E3 ubiquitin protein ligase family member 6, HERC6, HGNC:26072, MIM:609249, NM_001013000, NM_001013002, NM_001013005, NM_001165136, NM_017912, NP_001158608, NP_060382, XM_005263083, XM_011532053, XM_017008333, XP_005263140, XP_011530355, XP_016863822, XR_001741267
Omim:OMIM:609249
Id:ENSG00000138642
Hgnc:HGNC:26072
Entrez:55008
Ensembl:ENSG00000138642
Description:HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View HERC6's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with HERC6.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using HERC6.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for HERC6.

Submit
Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with HERC6.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE190937 AHCY MAT2A knockout Rael 4 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE110709 GSK-J4 5 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE233647 docetaxel UFERSA-PC3 DU145 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE108464 AZ-628 1 v 9 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE245968 FOXA1 inhibition Receptors Steroid Acetyltransferases 3 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE235587 mitoxantrone KYSE-70 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE146612 amiodarone 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE77829 SLIRP knockdown LNCaP 3 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE142210 9 V 1 PANOBINOSTAT HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE108464 AZ-628 6 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE190937 AHCY MAT2A knockout Rael 4 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE110709 GSK-J4 5 v 3 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE233647 docetaxel UFERSA-PC3 DU145 2 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE108464 AZ-628 1 v 9 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE245968 FOXA1 inhibition Receptors Steroid Acetyltransferases 3 v 2 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE235587 mitoxantrone KYSE-70 2 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE146612 amiodarone 2 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE77829 SLIRP knockdown LNCaP 3 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE142210 9 V 1 PANOBINOSTAT HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE108464 AZ-628 6 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

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    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.