CILP (Gene)

Organism:

Homo sapiens

Synonyms:CILP, CILP-1, ENTREZ:8483, HGNC:1980, HsT18872, MIM:603489, NM_003613, NP_003604, XM_017022678, XM_017022679, XP_016878167, XP_016878168, cartilage intermediate layer protein

Omim:OMIM:603489

Id:ENSG00000138615

Hgnc:HGNC:1980

Entrez:8483

Ensembl:ENSG00000138615

Description:cartilage intermediate layer protein

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CILP's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CILP.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CILP.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CILP.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CILP.

Results found

Linked to

	Label	Description
	GSE182157 AS3MT knockout SH-SY5Y 3 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE151090 verteporfin 5 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE217452 docetaxel 3 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE234148 HDAC inhibition 3 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE239844 crizotinib 7 v 10 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE151090 5 V 4 VERTEPORFIN HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE164874 prednisolone muscle organ 5 v 10 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE152699 GSE152723 vemurafenib 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE144843 GSE144844 SMARCA2 SMARCA4 knockdown 5 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE169356 FOXA1 inhibition prostate gland Ivermectin 2 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE182157 AS3MT knockout SH-SY5Y 3 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE151090 verteporfin 5 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE217452 docetaxel 3 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE234148 HDAC inhibition 3 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE239844 crizotinib 7 v 10 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE151090 5 V 4 VERTEPORFIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE164874 prednisolone muscle organ 5 v 10 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE152699 GSE152723 vemurafenib 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE144843 GSE144844 SMARCA2 SMARCA4 knockdown 5 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE169356 FOXA1 inhibition prostate gland Ivermectin 2 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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