GPNMB (Gene)

Entrez Gene ID: 10457

Description: glycoprotein nmb

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View GPNMB's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with GPNMB.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using GPNMB.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for GPNMB.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with GPNMB.

Gene Sets (6423)

LINCS L1000 Chem Pert Consensus Sigs (1580)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (5)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (27)

A gene set library provided by GlyGen

KOMP2 Mouse Phenotypes 2022 (2)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (1504)

A gene set library provided by LINCS

rummageo gene perturbations (196)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (2)

A gene set library provided by GTEx

RummaGEO DrugPerturbations 2025 (645)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (2116)

A gene set library provided by LINCS

rummageo chemical perturbations (332)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (12)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (2)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(2-((2-(methylsulfonyl)ethylamino)methyl)thiazol-4-yl)quinazolin-4-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GPNMB Gene (Entity type)	0.009980446
1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholino-1H-pyrazole-3-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GPNMB Gene (Entity type)	-0.003507165
2-(4-methylpiperazin-1-yl)quinoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GPNMB Gene (Entity type)	-0.010722661
ursodeoxycholyltaurine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GPNMB Gene (Entity type)	-0.0038327202
VU-0424206-1 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GPNMB Gene (Entity type)	0.013585943
Sertraline Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GPNMB Gene (Entity type)	0.009721558
Saracatinib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GPNMB Gene (Entity type)	0.0045916466
N-(4-(3-bromophenylamino)quinazolin-6-yl)acrylamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GPNMB Gene (Entity type)	0.009975718
Propylthiouracil Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GPNMB Gene (Entity type)	-0.007843759
SRT-1720 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GPNMB Gene (Entity type)	0.0072002104

N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(2-((2-(methylsulfonyl)ethylamino)methyl)thiazol-4-yl)quinazolin-4-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GPNMB
Gene (Entity type)
0.009980446

1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-morpholino-1H-pyrazole-3-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
GPNMB
Gene (Entity type)
-0.003507165

2-(4-methylpiperazin-1-yl)quinoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
GPNMB
Gene (Entity type)
-0.010722661

ursodeoxycholyltaurine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
GPNMB
Gene (Entity type)
-0.0038327202

VU-0424206-1
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GPNMB
Gene (Entity type)
0.013585943

Sertraline
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GPNMB
Gene (Entity type)
0.009721558

Saracatinib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GPNMB
Gene (Entity type)
0.0045916466

N-(4-(3-bromophenylamino)quinazolin-6-yl)acrylamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GPNMB
Gene (Entity type)
0.009975718

Propylthiouracil
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
GPNMB
Gene (Entity type)
-0.007843759

SRT-1720
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GPNMB
Gene (Entity type)
0.0072002104

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.