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CFDE Workbench

CARS2 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CARS2, COXPD27, ENTREZ:79587, HGNC:25695, MIM:612800, NM_001352252, NM_001352253, NM_024537, NP_001339181, NP_001339182, NP_078813, NR_147941, NR_147942, XM_006719953, XM_011521116, XM_011521117, XM_011521118, XM_017020741, XM_017020742, XM_024449409, XP_006720016, XP_011519418, XP_011519419, XP_011519420, XP_016876230, XP_016876231, XP_024305177, XR_001749664, XR_001749665, XR_001749666, XR_001749667, XR_001749668, XR_002957472, XR_243047, XR_243048, XR_243049, XR_243051, cysRS, cysteinyl-tRNA synthetase 2, mitochondrial
Omim:OMIM:612800
Id:ENSG00000134905
Hgnc:HGNC:25695
Entrez:79587
Ensembl:ENSG00000134905
Description:cysteinyl-tRNA synthetase 2, mitochondrial
This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CARS2's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CARS2.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CARS2.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CARS2.

Submit
Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CARS2.

Results found

Linked to

 

Label

Description

 

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GSE213588 trametinib NF1 8 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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GSE182150 KIT LSD1 MYC inhibition 2 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE163297 doxorubicin 0 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE218097 SOX10 overexpression glial cell 2 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE252944 AKT inhibition 7 v 9 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE254526 GSE254528 MI-1 Kasumi-1 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE214505 AKR1B1 knockdown A-549 3 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE142588 cinobufagin 2 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE168602 GSE168604 selumetinib COLO205 2 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE193993 SSTR2 knockout 4 v 7 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE213588 trametinib NF1 8 v 7 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE182150 KIT LSD1 MYC inhibition 2 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
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