LPIN1 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:23175, HGNC:13345, LPIN1, MIM:605518, NM_001261427, NM_001261428, NM_001261429, NM_001349199, NM_001349200, NM_001349201, NM_001349202, NM_001349203, NM_001349204, NM_001349205, NM_001349206, NM_001349207, NM_001349208, NM_145693, NP_001248356, NP_001248357, NP_001336128, NP_001336129, NP_001336130, NP_001336131, NP_001336132, NP_001336133, NP_001336134, NP_001336135, NP_001336136, NP_001336137, NP_663731, NR_146080, PAP1, XM_006711870, XM_006711872, XM_011510333, XM_011510334, XM_011510335, XM_011510336, XM_017003623, XM_017003624, XM_017003625, XM_017003627, XM_017003628, XM_017003629, XM_017003630, XM_017003631, XM_024452762, XM_024452763, XP_006711933, XP_006711935, XP_011508635, XP_011508636, XP_011508637, XP_011508638, XP_016859112, XP_016859113, XP_016859114, XP_016859116, XP_016859117, XP_016859118, XP_016859119, XP_016859120, XP_024308530, XP_024308531, lipin 1

Omim:OMIM:605518

Id:ENSG00000134324

Hgnc:HGNC:13345

Entrez:23175

Ensembl:ENSG00000134324

Description:lipin 1

This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View LPIN1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with LPIN1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using LPIN1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for LPIN1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with LPIN1.

Results found

Linked to

	Label	Description
	T60-Adrenal Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	T61-Colon Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE179112 GSE179113 hydroxyl Hutt45 4 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE118548 trametinib T84 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE252944 AKT inhibition 7 v 9 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE151412 sorafenib 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE142588 cinobufagin 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE190937 AHCY MAT2A knockout Rael 4 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE193993 SSTR2 knockout 1 v 7 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE158632 quinoline HT-29 Caco-2 2 v 4 human up Gene Set (Entity type)	A Gene Set from LINCS

T60-Adrenal Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

T61-Colon Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

GSE179112 GSE179113 hydroxyl Hutt45 4 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE118548 trametinib T84 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE252944 AKT inhibition 7 v 9 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE151412 sorafenib 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE142588 cinobufagin 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE190937 AHCY MAT2A knockout Rael 4 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE193993 SSTR2 knockout 1 v 7 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE158632 quinoline HT-29 Caco-2 2 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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