JCHAIN (Gene)

Entrez Gene ID: 3512

Description: joining chain of multimeric IgA and IgM

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View JCHAIN's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with JCHAIN.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using JCHAIN.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for JCHAIN.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with JCHAIN.

Gene Sets (7407)

LINCS L1000 Chem Pert Consensus Sigs (1989)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (6)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (77)

A gene set library provided by GlyGen

LINCS L1000 CRISPR KO Consensus Sigs (2055)

A gene set library provided by LINCS

rummageo gene perturbations (45)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (44)

A gene set library provided by GTEx

RummaGEO DrugPerturbations 2025 (146)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (2953)

A gene set library provided by LINCS

rummageo chemical perturbations (70)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (8)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (5)

A gene set library provided by GTEx

HuBMAP ASCT-B (9)

A gene set library provided by HuBMAP

Knowledge Graph Assertions

Source	Relation	Target	Evidence
ethopropazine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	JCHAIN Gene (Entity type)	-0.011455606
SA-90544 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	JCHAIN Gene (Entity type)	0.0127238715
NXY-059 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	JCHAIN Gene (Entity type)	0.0044093393
Trimetazidine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	JCHAIN Gene (Entity type)	0.0036136433
naloxone Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	JCHAIN Gene (Entity type)	0.0045674634
GR-144053 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	JCHAIN Gene (Entity type)	0.009869186
Entecavir Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	JCHAIN Gene (Entity type)	0.005345219
pterostilbene Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	JCHAIN Gene (Entity type)	0.0068484046
N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl]-methanesulfonamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	JCHAIN Gene (Entity type)	-0.03704699
BRL-54443 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	JCHAIN Gene (Entity type)	0.009281702

ethopropazine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
JCHAIN
Gene (Entity type)
-0.011455606

SA-90544
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
JCHAIN
Gene (Entity type)
0.0127238715

NXY-059
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
JCHAIN
Gene (Entity type)
0.0044093393

Trimetazidine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
JCHAIN
Gene (Entity type)
0.0036136433

naloxone
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
JCHAIN
Gene (Entity type)
0.0045674634

GR-144053
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
JCHAIN
Gene (Entity type)
0.009869186

Entecavir
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
JCHAIN
Gene (Entity type)
0.005345219

pterostilbene
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
JCHAIN
Gene (Entity type)
0.0068484046

N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydro-naphthalen-1-yl]-methanesulfonamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
JCHAIN
Gene (Entity type)
-0.03704699

BRL-54443
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
JCHAIN
Gene (Entity type)
0.009281702

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.