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CFDE Workbench

BCL2L2 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:BCL-W, BCL2 like 2, BCL2-L-2, BCL2L2, BCLW, ENTREZ:599, HGNC:995, MIM:601931, NM_001199839, NM_004050, NP_001186768, NP_004041, PPP1R51
Omim:OMIM:601931
Id:ENSG00000129473
Hgnc:HGNC:995
Entrez:599
Ensembl:ENSG00000129473
Description:BCL2 like 2
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View BCL2L2's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with BCL2L2.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using BCL2L2.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for BCL2L2.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with BCL2L2.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE89154 proscillaridin 1 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE89154 1 V 3 PROSCILLARIDIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE110709 GSK-J4 5 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE235701 GSE261434 enasidenib 2 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE156648 DOT1L overexpression IMR-90 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE146612 amiodarone 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE235066 carboplatin 4 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE182150 KIT LSD1 MYC inhibition 4 v 8 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE143948 ZNF213 knockdown MCF-7 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE202434 GSE202438 talazoparib 15 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE89154 proscillaridin 1 v 3 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE89154 1 V 3 PROSCILLARIDIN HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE110709 GSK-J4 5 v 3 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE235701 GSE261434 enasidenib 2 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE156648 DOT1L overexpression IMR-90 2 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE146612 amiodarone 2 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE235066 carboplatin 4 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE182150 KIT LSD1 MYC inhibition 4 v 8 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE143948 ZNF213 knockdown MCF-7 0 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE202434 GSE202438 talazoparib 15 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

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    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.