STAT1 (Gene)

Organism:

Homo sapiens

Synonyms:CANDF7, ENTREZ:6772, HGNC:11362, IMD31A, IMD31B, IMD31C, ISGF-3, MIM:600555, NM_001384880, NM_001384881, NM_001384882, NM_001384883, NM_001384884, NM_001384885, NM_001384886, NM_001384887, NM_001384888, NM_001384889, NM_001384890, NM_001384891, NM_007315, NM_139266, NP_001371809, NP_001371810, NP_001371811, NP_001371812, NP_001371813, NP_001371814, NP_001371815, NP_001371816, NP_001371817, NP_001371818, NP_001371819, NP_001371820, NP_009330, NP_644671, STAT1, STAT91, XM_006712718, XP_006712781, XR_001738914, XR_001738915, signal transducer and activator of transcription 1

Omim:OMIM:600555

Id:ENSG00000115415

Hgnc:HGNC:11362

Entrez:6772

Ensembl:ENSG00000115415

Description:signal transducer and activator of transcription 1

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View STAT1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with STAT1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using STAT1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for STAT1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with STAT1.

Results found

Linked to

	Label	Description
	GSE179112 GSE179113 hydroxyl Hutt45 4 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE158834 ADIPOR2 knockout HEK293 7 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE158834 7 V 3 PALMITIC ACID HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE190937 AHCY MAT2A knockout Rael 4 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE110709 GSK-J4 5 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE119978 GSE180930 cisplatin 3 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE233647 docetaxel UFERSA-PC3 DU145 2 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE156648 DOT1L overexpression IMR-90 2 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE133927 PTEN p53 Meox1 knockdown BT-549 RNA Small Interfering 1 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE153867 olaparib 6 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS

GSE179112 GSE179113 hydroxyl Hutt45 4 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE158834 ADIPOR2 knockout HEK293 7 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE158834 7 V 3 PALMITIC ACID HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE190937 AHCY MAT2A knockout Rael 4 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE110709 GSK-J4 5 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE119978 GSE180930 cisplatin 3 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE233647 docetaxel UFERSA-PC3 DU145 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE156648 DOT1L overexpression IMR-90 2 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE133927 PTEN p53 Meox1 knockdown BT-549 RNA Small Interfering 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE153867 olaparib 6 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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