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CFDE Workbench

RAPGEF2 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CNrasGEF, ENTREZ:9693, HGNC:16854, MIM:609530, NM_001351724, NM_001351725, NM_001351726, NM_001351727, NM_001351728, NM_001394067, NM_014247, NP_001338653, NP_001338654, NP_001338655, NP_001338656, NP_001338657, NP_001380996, NP_055062, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, RAGEF, RAPGEF2, Rap guanine nucleotide exchange factor 2, Rap-GEP, XM_005263358, XM_005263359, XM_005263360, XM_005263361, XM_006714420, XM_006714422, XM_011532425, XM_011532426, XM_017008856, XM_024454286, XM_024454287, XP_005263415, XP_005263416, XP_005263417, XP_005263418, XP_006714483, XP_006714485, XP_011530727, XP_011530728, XP_016864345, XP_024310054, XP_024310055, nRap GEP
Omim:OMIM:609530
Id:ENSG00000109756
Hgnc:HGNC:16854
Entrez:9693
Ensembl:ENSG00000109756
Description:Rap guanine nucleotide exchange factor 2
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

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Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View RAPGEF2's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with RAPGEF2.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using RAPGEF2.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for RAPGEF2.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with RAPGEF2.

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    Gene Set (Entity type)

    A Gene Set from LINCS

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    A Gene Set from LINCS

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    A Gene Set from LINCS

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    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
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    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
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