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CFDE Workbench

ALOX12 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:12-LOX, 12S-LOX, ALOX12, ENTREZ:239, HGNC:429, LOG12, MIM:152391, NM_000697, NP_000688, XM_011523780, XP_011522082, arachidonate 12-lipoxygenase, 12S type
Omim:OMIM:152391
Id:ENSG00000108839
Hgnc:HGNC:429
Entrez:239
Ensembl:ENSG00000108839
Description:arachidonate 12-lipoxygenase, 12S type
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View ALOX12's neighborhood in the knowledge graph.

Submit
Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with ALOX12.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using ALOX12.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for ALOX12.

Submit
Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with ALOX12.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE202434 GSE202438 talazoparib 4 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE129698 SYK inhibition 3 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE77108 saha 0 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE185519 4 V 5 GILTERITINIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE202434 GSE202438 talazoparib 4 v 14 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Phenotype

Sensorineural hearing impairment

Phenotype (Entity type)

A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlea...

Gene Set

GSE202434,GSE202438 4 V 0 TALAZOPARIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE188570 GSE188571 decitabine 5 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE129698 SYK inhibition 7 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE77108 0 V 2 SAHA HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE202434 GSE202438 talazoparib 4 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE129698 SYK inhibition 3 v 4 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE77108 saha 0 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE185519 4 V 5 GILTERITINIB HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE202434 GSE202438 talazoparib 4 v 14 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Phenotype

    Sensorineural hearing impairment

    Phenotype (Entity type)

    A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlea...

  • Gene Set

    GSE202434,GSE202438 4 V 0 TALAZOPARIB HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE188570 GSE188571 decitabine 5 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE129698 SYK inhibition 7 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE77108 0 V 2 SAHA HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.