SERPINE1 (Gene)

Entrez Gene ID: 5054

Description: serpin family E member 1

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SERPINE1's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SERPINE1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SERPINE1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SERPINE1.

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Gene Sets (1784)

LINCS L1000 Chem Pert Consensus Sigs (453)

A gene set library provided by LINCS

GlyGen Glycosylated Proteins 2022 (9)

A gene set library provided by GlyGen

KOMP2 Mouse Phenotypes 2022 (2)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (160)

A gene set library provided by LINCS

rummageo gene perturbations (272)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (20)

A gene set library provided by GTEx

LINCS L1000 Consensus Median Signatures (435)

A gene set library provided by LINCS

rummageo chemical perturbations (425)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (3)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (5)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINE1 Gene (Entity type)	-0.013363885
17-allyl-17-demethoxygeldanamycin Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINE1 Gene (Entity type)	-0.009190055
SA-1919877 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINE1 Gene (Entity type)	-0.011965461
pyridostigmine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SERPINE1 Gene (Entity type)	0.003214626
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINE1 Gene (Entity type)	-0.013575785
Hydroxyamphetamine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINE1 Gene (Entity type)	-0.04043398
KM-01366 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SERPINE1 Gene (Entity type)	0.009863005
(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SERPINE1 Gene (Entity type)	0.010108096
(4-Bromo-2-fluoro-phenyl)-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yl]-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINE1 Gene (Entity type)	-0.0038693831
HG-9-91-01 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SERPINE1 Gene (Entity type)	-0.005479081

5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINE1
Gene (Entity type)
-0.013363885

17-allyl-17-demethoxygeldanamycin
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINE1
Gene (Entity type)
-0.009190055

SA-1919877
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINE1
Gene (Entity type)
-0.011965461

pyridostigmine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SERPINE1
Gene (Entity type)
0.003214626

N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINE1
Gene (Entity type)
-0.013575785

Hydroxyamphetamine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINE1
Gene (Entity type)
-0.04043398

KM-01366
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SERPINE1
Gene (Entity type)
0.009863005

(2R,6aS,12aS)-2-Isopropenyl-8,9-dimethoxy-1,2,12,12a-tetrahydro-6aH-chromeno[3,4-b]furo[2,3-h]chromen-6-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SERPINE1
Gene (Entity type)
0.010108096

(4-Bromo-2-fluoro-phenyl)-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yl]-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINE1
Gene (Entity type)
-0.0038693831

HG-9-91-01
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SERPINE1
Gene (Entity type)
-0.005479081

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.