PCOLCE (Gene)

Entrez Gene ID: 5118

Description: procollagen C-endopeptidase enhancer

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PCOLCE's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PCOLCE.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PCOLCE.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PCOLCE.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PCOLCE.

Gene Sets (2849)

LINCS L1000 Chem Pert Consensus Sigs (613)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (3)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (1)

A gene set library provided by GlyGen

LINCS L1000 CRISPR KO Consensus Sigs (649)

A gene set library provided by LINCS

rummageo gene perturbations (115)

A gene set library provided by LINCS

RummaGEO DrugPerturbations 2025 (344)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (883)

A gene set library provided by LINCS

rummageo chemical perturbations (227)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (4)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (10)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
Trihexyphenidyl Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCOLCE Gene (Entity type)	-0.018763674
1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-yl-ethyl ester Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCOLCE Gene (Entity type)	-0.004989487
eicosadienoic-acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCOLCE Gene (Entity type)	0.012782704
2-[(S)-4-(4-Chloro-phenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-N-(4-hydroxy-phenyl)acetamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCOLCE Gene (Entity type)	-0.007971208
SID11113672 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCOLCE Gene (Entity type)	-0.04124668
2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCOLCE Gene (Entity type)	-0.006720639
Mesna Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCOLCE Gene (Entity type)	0.010209126
2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCOLCE Gene (Entity type)	-0.0048778574
SA-102787 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCOLCE Gene (Entity type)	0.016280347
SA-1456170 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCOLCE Gene (Entity type)	-0.016369868

Trihexyphenidyl
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCOLCE
Gene (Entity type)
-0.018763674

1-Phenyl-cyclohexanecarboxylic acid 2-morpholin-4-yl-ethyl ester
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCOLCE
Gene (Entity type)
-0.004989487

eicosadienoic-acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCOLCE
Gene (Entity type)
0.012782704

2-[(S)-4-(4-Chloro-phenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-N-(4-hydroxy-phenyl)acetamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCOLCE
Gene (Entity type)
-0.007971208

SID11113672
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCOLCE
Gene (Entity type)
-0.04124668

2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCOLCE
Gene (Entity type)
-0.006720639

Mesna
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCOLCE
Gene (Entity type)
0.010209126

2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCOLCE
Gene (Entity type)
-0.0048778574

SA-102787
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCOLCE
Gene (Entity type)
0.016280347

SA-1456170
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCOLCE
Gene (Entity type)
-0.016369868

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.