PCSK1N (Gene)

Entrez Gene ID: 27344

Description: proprotein convertase subtilisin/kexin type 1 inhibitor

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PCSK1N's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PCSK1N.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PCSK1N.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PCSK1N.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PCSK1N.

Gene Sets (2316)

LINCS L1000 Chem Pert Consensus Sigs (479)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (27)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (2)

A gene set library provided by GlyGen

KOMP2 Mouse Phenotypes 2022 (3)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (670)

A gene set library provided by LINCS

rummageo gene perturbations (86)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (7)

A gene set library provided by GTEx

RummaGEO DrugPerturbations 2025 (207)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (665)

A gene set library provided by LINCS

rummageo chemical perturbations (160)

A gene set library provided by LINCS

GTEx Tissues V8 2023 (10)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
AT1-SHH-09 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK1N Gene (Entity type)	-0.0032973336
PSH-003 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCSK1N Gene (Entity type)	0.009945091
SA-1920327 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCSK1N Gene (Entity type)	0.016270293
Formononetin Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCSK1N Gene (Entity type)	0.014846022
ST-4070043 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCSK1N Gene (Entity type)	0.009546383
odanacatib Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCSK1N Gene (Entity type)	0.0037999738
SA-1922927 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCSK1N Gene (Entity type)	0.0106567
Pergolide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK1N Gene (Entity type)	-0.007347831
dipropyl-5-CT Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PCSK1N Gene (Entity type)	-0.006727005

AT1-SHH-09
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCSK1N
Gene (Entity type)
-0.0032973336

PSH-003
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCSK1N
Gene (Entity type)
0.009945091

SA-1920327
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCSK1N
Gene (Entity type)
0.016270293

Formononetin
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCSK1N
Gene (Entity type)
0.014846022

ST-4070043
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCSK1N
Gene (Entity type)
0.009546383

odanacatib
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCSK1N
Gene (Entity type)
0.0037999738

SA-1922927
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCSK1N
Gene (Entity type)
0.0106567

Pergolide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCSK1N
Gene (Entity type)
-0.007347831

dipropyl-5-CT
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PCSK1N
Gene (Entity type)
-0.006727005

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Knowledge Graph Assertions

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.